Evidence map›Paper›PMID 41358318›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Bicuspid Aortic Valve in Heritable Thoracic Aortic Disease: Insights from the Montalcino Aortic Consortium.

Kishan L Asokan, Neha Muraly, Dongchuan Guo, Deep M Shah, Ernesto C Martinez, Elena Cervi, Julie De Backer, Laura Muiño Mosquera, Wannes Renders, Alan C Braverman and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Kishan L AsokanUniversity of Texas Health Science Center at Houston, Houston, TX, USA.
Neha MuralyUniversity of Texas Health Science Center at Houston, Houston, TX, USA.
Dongchuan GuoUniversity of Texas Health Science Center at Houston, Houston, TX, USA.
Deep M ShahUniversity of Texas Health Science Center at Houston, Houston, TX, USA.
Ernesto C MartinezUniversity of Texas Health Science Center at Houston, Houston, TX, USA.
Elena CerviGreat Ormond Street Hospital for Children, London, UK.
Julie De BackerGhent University Hospital, Ghent, Belgium.
Laura Muiño MosqueraGhent University Hospital, Ghent, Belgium.
Wannes RendersGhent University Hospital, Ghent, Belgium.
Alan C BravermanWashington University School of Medicine, St Louis, MO, USA.
Michelle LimCentral Sydney Cardiology, Sydney, Australia.
Maral OuzonianUniversity of Toronto, Toronto, Canada.
Richmond W JeremyCentral Sydney Cardiology, Sydney, Australia.
Shaine A MorrisBaylor College of Medicine, Houston, TX, USA.
Irina V VolguinaBaylor College of Medicine, Houston, TX, USA.
Talha NiazMayo Clinic, Rochester, MN, USA.
Anji T YetmanUniversity of Nebraska Medical Center, Omaha, NE, USA.
David W JantzenUniversity of Nebraska Medical Center, Omaha, NE, USA.
Gisela Teixido-TuraUniversity Hospital Vall d'Hebron, Barcelona, Spain.
Arturo EvangelistaUniversity Hospital Vall d'Hebron, Barcelona, Spain.
Guillaume JondeauHospital Bichat-Claude Bernard, Université Paris Cité, INSERM U1148, Paris, France.
Olivier MilleronHospital Bichat-Claude Bernard, Université Paris Cité, INSERM U1148, Paris, France.
Dianna M MilewiczUniversity of Texas Health Science Center at Houston, Houston, TX, USA.
Siddharth K PrakashUniversity of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0001-6341-9624

Funding

Genetic Predisposition To Thoracic Aortic Aneurysms/DissectionsR01HL109942 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MILEWICZ, DIANNA M · 2012 to 2023
$7.5M
NHLBI NIH HHS R01 HL109942
6 · The paper itself

Abstract

Bicuspid aortic valve (BAV) is the most common congenital heart malformation and predisposes to thoracic aortic aneurysms. The Montalcino Aortic Consortium (MAC) registry collects genetic and phenotypic data on individuals with heritable thoracic aortic disease genes (HTAD PVs) that primarily regulate smooth muscle cell contraction or TGF-β signaling (TGF-β PVs, termed Loeys-Dietz Syndrome (LDS)). We evaluated associations between BAV, HTAD PVs and aortic outcomes in the MAC cohort. BAV was present in 48 (6%) of 816 MAC participants (age 38 [IQR 20-52] years, 51% female) and was not significantly increased in males or in the entire TGF-β PV group (417 with TGF-β PVs, p=0.14) but was enriched in participants with

Indexed as

bicuspid aortic valvecardiovascular geneticscongenital heart diseaseThoracic aortic aneurysms and dissections

Identifiers

PMID41358318
PMCPMC12676545

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.