ArticleWorld journal of gastroenterology2025
Bile acid dysmetabolism in Bangladeshi infants associated with poor linear growth, enteric inflammation, and small intestine bacterial overgrowth.
Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEnvironmental enteric dysfunction (EED) is a subclinical condition caused by fecal-oral contamination leading to enteric inflammation and dysbiosis. Bile acids serve to facilitate lipid digestion and absorption, regulate metabolic pathways associated with childhood growth and inflammation, and may be affected by EED.
aimTo investigate bile acid metabolism in Bangladeshi children with EED and its association with growth impairment.
methodsWe conducted a cross-sectional study of 100 Bangladeshi infants (aged 6-9 months) and quantified serum and fecal bile acids using LC-MS/MS. We compared profiles to a control group of 6 American children (6-12 months) and 80 older Bangladeshi children (aged 2 years).
resultsBangladeshi infants had higher levels of plasma unconjugated primary (65.23%
conclusionOur data suggests an age-dependent defect in conjugation of primary bile acids in Bangladeshi children with compensatory hydrophilic shunting. Additionally, bile acid profiles are associated with intestinal overgrowth.
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