Evidence map›Paper›PMID 41358169›Full record

ArticleWorld journal of gastroenterology2025

Peripheral blood lymphocyte subset deficiency in acute-on-chronic liver failure and reconstitution following liver transplantation.

Bo Peng, Zhi-Xin Li, Min Yang, Kai Liu, Xu-Yu Xiang, Ying Zhang, Jun-Hui Li, Peng-Peng Zhang, Quan Zhuang, Ke Cheng and 1 more

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Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Bo PengTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Zhi-Xin LiDepartment of General Surgery, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Min YangTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Kai LiuTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Xu-Yu XiangTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Ying ZhangTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Jun-Hui LiTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Peng-Peng ZhangTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Quan ZhuangTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Ke ChengTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Ying-Zi MingTransplantation Center, The Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with acute-on-chronic liver failure (ACLF) experience severe immune dysfunction. Liver transplantation (LT) significantly improves survival outcomes. However, the characteristics of peripheral blood lymphocyte subsets (PBLSs) in this patient population are not well defined, and the dynamics of immune reconstitution post-LT are insufficiently understood.

aimTo characterize PBLSs in patients with ACLF prior to LT and to evaluate PBLS reconstitution after LT.

methodsClinical data from patients undergoing LT in the Transplantation Center, The Third Xiangya Hospital from January 2022 to December 2023 were analyzed retrospectively. Our cohort comprised 44 patients with ACLF, 16 patients with acute decompensation of cirrhosis, and 23 patients with compensated cirrhosis. Twenty healthy volunteers were included as controls. PBLSs were evaluated across all groups. The relationship between PBLSs and post-LT prognosis was assessed, and dynamic changes in PBLSs among patients with ACLF were analyzed at different time points.

resultsPatients with ACLF exhibited a marked reduction in PBLSs compared with healthy volunteers. Natural killer (NK) cell counts were further reduced in patients with ACLF when compared with patients with compensated cirrhosis. PBLSs did not correlate with the etiology or severity of ACLF or with established liver failure scores. Following LT, a rapid restoration of NK cells and B cells was observed in patients with ACLF. However, the cluster of differentiation (CD) 3

conclusionPatients with ACLF exhibited markedly reduced PBLSs, with decreased NK cells potentially linked to progression from compensated cirrhosis to liver failure. NK and B cell were rapidly restored after LT.

Indexed as

Acute-On-Chronic Liver FailureImmune ReconstitutionLiver TransplantationLymphocyte SubsetsAdultCase-Control StudiesFemaleHumansKiller Cells, NaturalLiver CirrhosisLymphocyte CountMaleMiddle AgedPrognosisRetrospective StudiesTreatment OutcomeAcute-on-chronic liver failureImmune reconstitutionLiver transplantationPeripheral blood lymphocyte subsetPostoperative prognosis

Identifiers

PMID41358169
PMCPMC12678943

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