Evidence map›Paper›PMID 41358132›Full record

ArticleACS omega2025

Therapeutic Potential of Partial Retinoid Agonists against Vertebrate Rhodopsin Misfolding Disorders.

Zaiddodine Pashandi, Mingda Liu, Maria Azam, Sourav Das, Mordechai Sheves, Beata Jastrzebska

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zaiddodine PashandiDepartment of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106, United States.
Mingda LiuDepartment of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106, United States.
Maria AzamDepartment of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106, United States.
Sourav DasDepartment of Chemistry, Weizmann Institute of Science, Rehovot 7610001, Israel.
Mordechai ShevesDepartment of Chemistry, Weizmann Institute of Science, Rehovot 7610001, Israel.ORCID https://orcid.org/0000-0002-5048-8169
Beata JastrzebskaDepartment of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106, United States.ORCID https://orcid.org/0000-0001-5209-8685

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
Novel neuroprotective activities of flavonoids against retinal degenerative diseasesR01EY032874 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI JASTRZEBSKA, BEATA · 2022 to 2025
$1.9M
Cole Eye Institute Vision Science Training ProgramT32EY024236 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI ANAND-APTE, BELA · 2015 to 2025
$1.0M
Predoctoral Training in Molecular PharmacologyT32GM158814 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI Jason Mears, Marvin Thomas Nieman · 2025 to 2026
$858k
NEI NIH HHS P30 EY011373NEI NIH HHS R01 EY032874NEI NIH HHS T32 EY024236NIGMS NIH HHS T32 GM158814
6 · The paper itself

Abstract

Mutations in rod opsin are a leading cause of inherited retinal degenerative diseases such as retinitis pigmentosa (RP). Pharmacological compounds that stabilize rhodopsin (Rho) and mitigate cellular stress pathways hold promise for therapeutic intervention. Among these, retinoid analogs have shown efficacy in models of autosomal dominant RP (adRP) and age-related macular degeneration (AMD). In this study, we evaluated the pharmacological potential of two partial retinoid agonists, acyclic-retinal and 9-

Identifiers

PMID41358132
PMCPMC12676331

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.