Evidence map›Paper›PMID 41358076›Full record

ArticleACS omega2025

Comparative Mechanistic Insights into Quercetin-Loaded Selenium Nanoparticles and Cisplatin in HCT116 Cells.

Sahar Alsubaie, Nada Merghani, Manal Abudawood, Nikhat J Siddiqi, Sabiha Fatima

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PubMed Full text at PMC Publisher
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Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sahar AlsubaieDepartment of Clinical Laboratory Science, College of Applied Medical Sciences, King Saud University, Riyadh 12371, Saudi Arabia.
Nada MerghaniCentral Research Laboratory, King Saud University, Riyadh 12371, Saudi Arabia.
Manal AbudawoodDepartment of Clinical Laboratory Science, College of Applied Medical Sciences, King Saud University, Riyadh 12371, Saudi Arabia.
Nikhat J SiddiqiDepartment of Medical Surgical Nursing, College of Nursing, King Saud University, Riyadh 11451, Saudi Arabia.ORCID https://orcid.org/0000-0002-4830-3217
Sabiha FatimaDepartment of Clinical Laboratory Science, College of Applied Medical Sciences, King Saud University, Riyadh 12371, Saudi Arabia.ORCID https://orcid.org/0000-0001-8641-1369

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with rising incidence, treatment resistance, and chemotherapy-induced toxicity underscoring the need for safer, more effective therapeutic strategies. Nanotechnology offers a promising approach through targeted drug delivery and enhanced therapeutic efficacy. This study investigates the anticancer potential of quercetin-loaded selenium nanoparticles (Qu-SeNPs) against HCT116 colorectal cancer cells and directly compares their effects with cisplatin (CP). To our knowledge, this is the first study to systematically compare the mechanistic actions of Qu-SeNPs and CP in CRC cells. Comprehensive physicochemical characterization using UV-vis spectroscopy, FTIR, TEM, EDX, zeta potential, and DLS confirmed successful synthesis of stable, well-dispersed Qu-SeNPs, exhibiting a characteristic peak at 410 nm. MTT assays demonstrated that Qu-SeNPs reduced HCT116 cell viability in a dose-dependent manner, with an IC

Identifiers

PMID41358076
PMCPMC12676340

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.