Evidence map›Paper›PMID 41358026›Full record

ArticleChemical science2026

Bulky alkali metal cations enabled highly efficient iridium-catalyzed asymmetric hydrogenation for C-N axial chirality

Xianghua Zhao, Xinyu Chen, Linxian Fan, Yulong Jiang, Yirui Chen, Dingguo Song, Fei Ling, Junyuan Hu, Weihui Zhong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xianghua ZhaoState Key Laboratory of Green Chemical Synthesis and Conversion, College of Pharmaceutical Sciences, Zhejiang University of Technology Hangzhou 310014 P. R. China lingfei@zjut.edu.cn weihuizhong@zjut.edu.cn.
Xinyu ChenState Key Laboratory of Green Chemical Synthesis and Conversion, College of Pharmaceutical Sciences, Zhejiang University of Technology Hangzhou 310014 P. R. China lingfei@zjut.edu.cn weihuizhong@zjut.edu.cn.
Linxian FanState Key Laboratory of Green Chemical Synthesis and Conversion, College of Pharmaceutical Sciences, Zhejiang University of Technology Hangzhou 310014 P. R. China lingfei@zjut.edu.cn weihuizhong@zjut.edu.cn.
Yulong JiangState Key Laboratory of Green Chemical Synthesis and Conversion, College of Pharmaceutical Sciences, Zhejiang University of Technology Hangzhou 310014 P. R. China lingfei@zjut.edu.cn weihuizhong@zjut.edu.cn.
Yirui ChenState Key Laboratory of Green Chemical Synthesis and Conversion, College of Pharmaceutical Sciences, Zhejiang University of Technology Hangzhou 310014 P. R. China lingfei@zjut.edu.cn weihuizhong@zjut.edu.cn.
Dingguo SongHuzhou Key Laboratory of Medical and Environmental Applications Technologies, School of Life Sciences, Huzhou University Huzhou 313000 P. R. China.
Fei LingState Key Laboratory of Green Chemical Synthesis and Conversion, College of Pharmaceutical Sciences, Zhejiang University of Technology Hangzhou 310014 P. R. China lingfei@zjut.edu.cn weihuizhong@zjut.edu.cn.ORCID https://orcid.org/0000-0002-4274-912X
Junyuan HuSchool of Chemistry and Chemical Engineering, Shandong University Jinan 250100 People's Republic of China hujy2023@163.com.ORCID https://orcid.org/0009-0000-5954-7260
Weihui ZhongState Key Laboratory of Green Chemical Synthesis and Conversion, College of Pharmaceutical Sciences, Zhejiang University of Technology Hangzhou 310014 P. R. China lingfei@zjut.edu.cn weihuizhong@zjut.edu.cn.ORCID https://orcid.org/0000-0003-0349-2226

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The addition of excess alkali metal to Noyori-type catalysts (HM-NH) generates anionic species (HM-NM'), which significantly enhances both the reaction rate and turnover number (TON) in asymmetric hydrogenation. However, such anionic catalysts have been largely confined to the construction of central chirality, with few reports on application to axial chirality. Herein, we report a highly efficient anionic iridium catalyst (HIr-NCs) based on a newly tridentate ligand framework (Huaphos), which enables the asymmetric hydrogenation of

Identifiers

PMID41358026
PMCPMC12679508

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.