Trial reportClinical interventions in aging2025
Effect of Intraoperative Blood Pressure Levels on Postoperative Recovery in Frail Elderly Patients: A Randomized Controlled Trial.
Trial report in Clinical interventions in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Spinal Versus General Anesthesia for Acute Kidney Injury and Transfusion in One-Week-Staged Bilateral Total Knee Arthroplasty.Journal of clinical medicine · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Frailty is a clinical syndrome characterized by a reduction in the functional capacity of multiple physiological systems, which increases the body's vulnerability to stressors and reduces the capacity of elderly patients to recover from stressful events such as anesthesia and surgery. Methods: A total of 142 elderly frailty patients scheduled for total knee arthroplasty were randomly assigned to either the low-level (Group L) or high-level group (Group H). Group L maintained intraoperative mean arterial pressure (MAP) at 65-85 mmHg, while Group H targeted 85-100 mmHg. The primary outcome was the Quality of Recovery-15 (QoR-15) score on postoperative day (POD) 1. Secondary outcomes include the time-weighted average mean arterial pressure (TWA-MAP) intraoperatively, QoR-15 scores on POD2-5, the abbreviated mental test score (AMTS) at 30 days and 1-year postoperatively, the incidence of myocardial injury after noncardiac surgery (MINS) and acute kidney injury (AKI), 1-year mortality postoperatively. Results: There was no significant difference in QoR-15 values on POD1 between Group L and Group H (mean [SD] 99 [9.89] vs 98 [12.82], mean difference 95% confidence interval (CI) 0.91 (-3.08-4.91)). TWA-MAP was 93.1 ± 2.29 mmHg in Group H and 78.6 ± 2.97 mmHg in Group L (P < 0.05, mean difference 95% CI -14.5 (-15.4, -13.6)), indicating a statistically significant difference between the two groups. Conclusion: Maintaining higher or lower MAP intraoperatively had no significant effect on the quality of postoperative recovery in elderly frailty patients undergoing knee arthroplasty under the conditions studied in this trial.
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