Evidence map›Paper›PMID 41357969›Full record

ArticlebioRxiv : the preprint server for biology2025

Systematic Discovery of Novel Phosphoinositide-Binding Effectors in

Abigail E Bolt, Abby E Richardson, Colleen M Pike, Rebecca R Noll, Yanbao Yu, Joshua P Neunuebel, Sylvain Le Marchand, Karl R Schmitz, M Ramona Neunuebel

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Abigail E BoltDepartment of Biological Sciences, University of Delaware, Newark, DE, USA 19716.
Abby E RichardsonDepartment of Biological Sciences, University of Delaware, Newark, DE, USA 19716.
Colleen M PikeDepartment of Biological Sciences, University of Delaware, Newark, DE, USA 19716.
Rebecca R NollDepartment of Biological Sciences, University of Delaware, Newark, DE, USA 19716.
Yanbao YuDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE, USA 19716.ORCID 0000-0003-2994-1974
Joshua P NeunuebelData Science Institute and Department of Psychological and Brain Sciences, University of Delaware, Newark, DE, USA 19716.ORCID 0000-0002-4894-4364
Sylvain Le MarchandDepartment of Biological Sciences, University of Delaware, Newark, DE, USA 19716.
Karl R SchmitzDepartment of Biological Sciences, University of Delaware, Newark, DE, USA 19716.ORCID 0000-0003-1411-7624
M Ramona NeunuebelDepartment of Biological Sciences, University of Delaware, Newark, DE, USA 19716.ORCID 0000-0002-3113-7144

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Shawn W Polson · 2012 to 2026
$67.2M
This renovation project will create over 1455 sq. ft. of state- of-the-art reseaP20GM104316 · NIGMS · UNIVERSITY OF DELAWARE · PI FOX, JOSEPH M · 2014 to 2024
$26.8M
Pilot Research Subproject ProgramP30GM110758 · NIGMS · UNIVERSITY OF DELAWARE · PI POLENOVA, TATYANA · 2014 to 2018
$5.8M
Chemistry-Biology Interface Predoctoral Training Grant 2024-2029T32GM133395 · NIGMS · UNIVERSITY OF DELAWARE · PI Catherine Leimkuhler Grimes · 2019 to 2026
$3.7M
Phosphoarginine-linked protein quality control and stress responses in mycobacteriaR01AI171196 · NIAID · UNIVERSITY OF DELAWARE · PI Karl Robert Schmitz · 2024 to 2026
$1.1M
Zeiss LSM710 Inverted Confocal MicroscopeS10OD016361 · OD · UNIVERSITY OF DELAWARE · PI CAPLAN, JEFFREY L · 2015 to 2015
$444k
Characterization of Legionella effectors targeting host membrane compartmentsR21AI142317 · NIAID · UNIVERSITY OF DELAWARE · PI NEUNUEBEL, MARIA RAMONA · 2019 to 2020
$415k
NIAID NIH HHS R01 AI171196NIAID NIH HHS R21 AI142317NIGMS NIH HHS P20 GM103446NIGMS NIH HHS P20 GM104316NIGMS NIH HHS P30 GM110758NIGMS NIH HHS T32 GM133395NIH HHS S10 OD016361
6 · The paper itself

Abstract

Intracellular bacterial pathogens deploy effector proteins to hijack host membranes by targeting specific lipids. Phosphoinositides are key eukaryotic signaling molecules that govern membrane identity and dynamics, making them powerful levers for microbial interference. However, the bacterial repertoire of phosphoinositide-binding effectors remains largely undefined. In this study, we systematically identified such proteins using an expression library of 241

Indexed as

BurkholderiaCoxiellahelical foldhost-pathogen interactionsLegionellamembrane targetingphosphoinositide lipids

Identifiers

PMID41357969
PMCPMC12676380

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.