Evidence map›Paper›PMID 41357946›Full record

ArticleWorld journal of psychiatry2025

Neural correlates of conditional reasoning dysfunction in major depression: An event-related potential study with the Wason selection task.

Jia-Xv Li, Mei-Chen Lu, Luo-An Wu, Wei Li, Yu Li, Xin-Ping Li, Xiao-Hong Liu, Xue-Zheng Gao, Zhen-He Zhou, Hong-Liang Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jia-Xv LiDepartment of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, Training Base of Hubei University of Medicine, Shiyan 442000, Hubei Province, China.
Mei-Chen LuDepartment of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, Wuxi 214151, Jiangsu Province, China.
Luo-An WuDepartment of Psychiatry, The Yixing Fifth People's Hospital, Yixing 214200, Jiangsu Province, China.
Wei LiDepartment of Psychiatry, The Yixing Fifth People's Hospital, Yixing 214200, Jiangsu Province, China.
Yu LiDepartment of Psychiatry, The Yixing Fifth People's Hospital, Yixing 214200, Jiangsu Province, China.
Xin-Ping LiDepartment of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, Training Base of Hubei University of Medicine, Shiyan 442000, Hubei Province, China.
Xiao-Hong LiuDepartment of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, Wuxi 214151, Jiangsu Province, China.
Xue-Zheng GaoDepartment of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, Wuxi 214151, Jiangsu Province, China.
Zhen-He ZhouDepartment of Psychiatry, The Affiliated Mental Health Center of Jiangnan University, Training Base of Hubei University of Medicine, Shiyan 442000, Hubei Province, China.
Hong-Liang ZhouDepartment of Psychology, The Affiliated Hospital of Jiangnan University, Wuxi 214151, Jiangsu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with major depression (MD) exhibit conditional reasoning dysfunction; however, no studies on the event-related potential (ERP) characteristics of conditional reasoning in MD have been reported.

aimTo investigate the ERP characteristics of conditional reasoning in MD patients and explore the neural mechanism of cognitive processing.

methodsThirty-four patients with MD and 34 healthy controls (HCs) completed ERP measurements while performing the Wason selection task (WST). The cluster-based permutation test in FieldTrip was used to compare the differences in the mean amplitudes between the patients with MD and HCs on the ERP components under different experimental conditions. Behavioral data [accuracy (ACC) and reaction times (RTs)], the ERP P100 and late positive potentials (LPPs) were analyzed.

resultsAlthough the mean ACC was greater and the mean of RTs was shorter in HCs than in MD patients, the differences were not statistically significant. However, across both groups, the ACC in the precautionary WST was greater than that in the other tasks, and the RTs in the abstract task were greater than those in the other tasks. Importantly, compared with that of HCs, the P100 of the left centroparietal sites was significantly increased, and the early LPP was attenuated at parietal sites and increased at left frontocentral sites; the medium LPP and late LPP were increased at the left frontocentral sites.

conclusionPatients with MD have conditional reasoning dysfunction and exhibit abnormal ERP characteristics evoked by the WST, which suggests neural correlates of abnormalities in conditional reasoning function in MD patients.

Indexed as

Conditional reasoningEvent-related potentialMajor depressionNeural mechanismWason selection task

Identifiers

PMID41357946
PMCPMC12679128

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.