ArticleWorld journal of psychiatry2025
Exploratory analysis of symptom-specific efficacy of transcranial magnetic stimulation in adolescent depression.
Article in World journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdolescent depression manifests through diverse, interconnected symptoms, yet the clinical profile in patients treated with repetitive transcranial magnetic stimulation (rTMS) remains inadequately characterized. While rTMS shows therapeutic potential, its efficacy may be overestimated due to limited research and symptom heterogeneity. Identifying key symptom clusters and evaluating their predictive value for treatment response is crucial for optimizing rTMS outcomes in this population.
aimTo identify adolescent depression symptom clusters and assess their differential responses to rTMS treatment.
methodsOne hundred adolescent patients with first-episode major depressive disorder were randomized into control and study groups. Both groups received sertraline treatment, while the study group additionally underwent 10 sessions of adjunctive rTMS. Depressive symptoms were evaluated using the 17-item Hamilton Depression Rating Scale (HAMD-17) at baseline, week 2, and week 4.
resultsHierarchical clustering revealed four distinct symptom clusters: Subjective mood, impaired activity, somatic concerns, and anxiety/insomnia. The main effect of treatment visit showed significant decreases in symptom severity across all clusters. In the study group, the effect size between baseline and week 4 was largest for the subjective mood cluster (Cohen's d = 2.41) and smallest for somatic concerns (Cohen's d = 0.59). In the control group, the largest effect size was observed in the anxiety/insomnia cluster (Cohen's d = 1.20), with the smallest effect in impaired activity (Cohen's d = 0.47).
conclusionThis study identified four distinct symptom clusters with differential responses to rTMS treatment. The findings demonstrate that rTMS shows greatest efficacy for improving subjective mood symptoms, guiding targeted therapeutic approaches.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.