ArticleWorld journal of psychiatry2025
Relationship between anxiety and depression, dyspnea severity, and pulmonary function in connective tissue disease-associated interstitial lung disease.
Article in World journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Initial Dosage Optimization of Tacrolimus in Connective Tissue Disease-Associated Interstitial Lung Disease Patients: An Exploratory Study.Drug design, development and therapy · 2026Article
- Psychiatric comorbidities in patients with interstitial lung diseases: A narrative review of epidemiology, clinical impact, and integrated care strategies.Therapeutic advances in respiratory diseaseReview
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3 authors.
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Abstract
backgroundPatients with connective tissue disease-associated interstitial lung disease (CTD-ILD) experience not only progressive respiratory impairment but also a significant psychological burden. The prevalence and impact of anxiety and depression and their intricate relationship with dyspnea severity and pulmonary function decline remain inadequately characterized in this population, hindering comprehensive care.
aimTo explore the incidence of anxiety and depression in CTD-ILD and its relationship with dyspnea severity and pulmonary function index.
methodsData of 100 patients with CTD-ILD (January 2022-June 2024) were retrospectively analyzed. Baseline demographic, pulmonary function [forced vital capacity (FVC%) and diffusing capacity of the lungs for carbon monoxide (DLCO%)], modified medical research council (mMRC) score, and psychological scale [generalized anxiety disorder-7 (GAD-7) and patient health questionnaire-9 (PHQ-9)] were collected. Pulmonary function was reviewed every 3 months, and high-resolution computed tomography was performed every 6 months following standardized treatment (glucocorticoids + immunosuppressive + anti-fibrosis agents). Pearson/Spearman correlation analysis, linear mixed effect model, and Cox regression were used to analyze the correlation between anxiety and depression and physiological indicators as well as the prognosis.
resultsBaseline prevalence of moderate-to-severe anxiety (GAD-7 ≥ 10) and depression (PHQ-9 ≥ 10) was 38% and 42%, respectively. Following 24 weeks of treatment, pulmonary function (FVC%: 72.11 ± 13.08
conclusionAnxiety and depression in patients with CTD-ILD constituted a bidirectional negative feedback loop involving pulmonary function impairment, inflammatory activity, and dyspnea. Psychological disorders were identified as independent risk factors for deterioration of pulmonary function. Psychological evaluation and intervention should be integrated clinically to block brain-lung axis-mediated neuroendocrine-immune network imbalance and improve prognosis.
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