Evidence map›Paper›PMID 41357885›Full record

ArticleFrontiers in pharmacology2025

Evaluation of long-term safety profile of an EU-GMP certified

Gabriela-Dumitrita Stanciu, Ivona Costachescu, Daniela-Carmen Ababei, Andrei Szilagyi, Raluca-Maria Gogu, Vlad-Constantin Craciun, Andrei-Daniel Timofte, Irina-Draga Caruntu, Cristina-Elena Dobre, Bogdan-Ionel Tamba

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gabriela-Dumitrita Stanciu *Advanced Research and Development Center for Experimental Medicine "Prof. Ostin C. Mungiu" - CEMEX, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania.
Ivona Costachescu *Advanced Research and Development Center for Experimental Medicine "Prof. Ostin C. Mungiu" - CEMEX, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania.
Daniela-Carmen AbabeiPharmacodynamics and Clinical Pharmacy Department, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania.
Andrei SzilagyiAdvanced Research and Development Center for Experimental Medicine "Prof. Ostin C. Mungiu" - CEMEX, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania.
Raluca-Maria GoguAdvanced Research and Development Center for Experimental Medicine "Prof. Ostin C. Mungiu" - CEMEX, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania.
Vlad-Constantin CraciunDepartment of Computer Science, "Alexandru Ioan Cuza" University of Iasi, Iasi, Romania.
Andrei-Daniel TimofteDepartment of Morphofunctional Sciences 1, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania.
Irina-Draga CaruntuDepartment of Morphofunctional Sciences 1, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania.
Cristina-Elena DobreSocola Institute of Psychiatry Iasi, Iasi, Romania.
Bogdan-Ionel TambaAdvanced Research and Development Center for Experimental Medicine "Prof. Ostin C. Mungiu" - CEMEX, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is characterized in part by chronic, low-grade inflammation, a major driver of cognitive decline, metabolic imbalance and organ dysfunction. Despite its central role in age-related morbidity, pharmacological strategies with well-defined long-term safety profiles remain limited. Phytocannabinoids have been proposed as modulators of neuroinflammatory and metabolic pathways, but their chronic safety during natural aging is poorly characterized. Our team has previously reported the acute and 28-day repeated-dose toxicity profile of an EU-GMP certified

Indexed as

Cannabis sativa L.chronic intermittent therapyEU-GMP certificationinflammaginglong-term safety profilenatural agingpreclinical model

Identifiers

PMID41357885
PMCPMC12675448

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.