SynthesisFrontiers in pharmacology2025
Therapeutic effect and safety of Wei-Fu-Chun in the treatment of chronic atrophic gastritis: a network meta-analysis.
Synthesis in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Authors and funding
2 authors.
Funding
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Abstract
Introduction: Chronic atrophic gastritis (CAG) is a chronic condition characterized by a reduction in gastric mucosal glands and is often regarded as a precursor to gastric cancer. Currently, Western medicine lacks specific treatments for CAG, with management primarily focusing on symptomatic relief and, in cases involving Methods: We systematically reviewed randomized controlled trials (RCTs) comparing WFC with other interventions for CAG. The outcomes assessed included clinical effectiveness, gastrointestinal symptom scores, gastrointestinal hormone levels, and adverse reactions. The quality of the included studies was assessed with the Cochrane Handbook and GRADEpro software based on the following criteria: random sequence generation, allocation concealment, blinding of participants and personnel, blinding of outcome assessment, completeness of outcome data, and selective reporting. Risk ratios were calculated for dichotomous outcomes, and standardized mean differences with 95% confidence intervals were used for continuous variables. Funnel plots were generated to assess publication bias, and treatments were ranked using the surface under the cumulative ranking curve (SUCRA). Data analysis was performed using STATA 15.0 and Review Manager 5.3. The protocol has been registered with PROSPERO under the registration number CRD420251056533. Results: A total of 38 RCTs involving 3,844 participants were included, and 10 interventions were evaluated: conventional therapy, prokinetics, mucosal-protective agents (MPAs), acid-suppressing drugs (ASDs), Conclusion: WFC, particularly in combination with Western medications, enhances clinical efficacy and reduces the incidence of adverse events in patients with CAG. These findings support its potential as a therapeutic option for improving clinical outcomes in CAG. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, identifier CRD420251056533.
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Registered trials
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