ArticleFrontiers in pharmacology2025
Ivarmacitinib improves patient-reported outcomes across multiple domains in patients with active ankylosing spondylitis: a
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Targeting macrophage-mediated TGF-β/BMP signaling in ankylosing spondylitis: from inflammation to pathological bone formation.Frontiers in immunology · 2026Review
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Authors and funding
6 authors.
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Abstract
Background: Ivarmacitinib (SHR0302), a selective Janus kinase 1 inhibitor, has demonstrated substantial improvements in patients with active ankylosing spondylitis (AS). This Methods: Patients were assigned to receive either ivarmacitinib 4 mg (n = 187) or placebo (n = 186) daily for 12 weeks. Patients receiving placebo switched to ivarmacitinib thereafter until week 24. PROs included total back pain and night pain by visual analog scale (VAS), morning stiffness, Patient Global Assessment of Disease Activity (PtGA), AS Quality of Life (ASQol), 36-Item Short Form Health Survey (SF-36), Bath AS Disease Activity Index (BASDAI), and Bath AS Functional Index (BASFI). Results: Ivarmacitinib group showed significantly improvement in total back pain VAS ( Conclusion: Ivarmacitinib significantly enhances multiple dimensions of PROs in active AS patients, supporting its utility in managing PROs in AS. Switching to ivarmacitinib also provides substantial benefits, this indicates that initiating ivarmacitinib treatment, even after an initial period of placebo leads to meaningful improvements in PROs.
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