Evidence map›Paper›PMID 41357849›Full record

ArticleRegenerative biomaterials2025

Rhodiola rosea-derived exosome-like nanovesicles inhibit vascular endothelial pyroptosis in the treatment of limb skeletal muscle ischemic injury through the TXNIP/NLNP3 pathway.

Dachang Liu, Zhibin Zhang, Yuchao Wang, Xiaoyu Liang, Yun Chang, Changduo Wang, Yaming Guo, Shijie Zhang, Jianghui Zhou, Meng Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dachang LiuSchool of Medicine, Nankai University, Tianjin 300071, China.
Zhibin ZhangSchool of Medicine, Nankai University, Tianjin 300071, China.
Yuchao WangSchool of Medicine, Nankai University, Tianjin 300071, China.
Xiaoyu LiangSchool of Medicine, Nankai University, Tianjin 300071, China.
Yun ChangSchool of Medicine, Nankai University, Tianjin 300071, China.
Changduo WangState Key Laboratory of Advanced Medical Materials and Devices, Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China.
Yaming GuoState Key Laboratory of Advanced Medical Materials and Devices, Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China.
Shijie ZhangSchool of Medicine, Nankai University, Tianjin 300071, China.
Jianghui ZhouTianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin University Central Hospital; Department of Heart Center, The Third Central Hospital of Tianjin; Nankai University Affiliated Third Center Hospital; The Third Central Clinical College of Tianjin Medical University, Tianjin 300170, China.
Meng ZhangTianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin University Central Hospital; Department of Heart Center, The Third Central Hospital of Tianjin; Nankai University Affiliated Third Center Hospital; The Third Central Clinical College of Tianjin Medical University, Tianjin 300170, China.
Hechen ShenDepartment of Thoracic Surgery, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610000, China.
Xuesong ZhangSchool of Medicine, Nankai University, Tianjin 300071, China.
Wenqing GaoSchool of Medicine, Nankai University, Tianjin 300071, China.ORCID https://orcid.org/0009-0008-4824-3489

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscle ischemia, resulting from impaired blood flow, is a prevalent clinical issue and a leading cause of amputation. Plant-derived exosome-like nanovesicles (ELNs) have emerged as promising candidates due to their diverse bioactive components with antioxidant, anti-inflammatory and regenerative properties. In this study, exosome-like nanovesicles (RhELNs) extracted from the root of Rhodiola rosea, a traditional Chinese medicine, were proved to have a good ability to promote the regeneration of vascular endothelial cells under hypoxia by EdU experiment and transwell experiment

Indexed as

RhELNsskeletal musclevascular

Identifiers

PMID41357849
PMCPMC12681252

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.