Evidence map›Paper›PMID 41357834›Full record

ArticleFrontiers in neuroscience2025

Histological analysis of thrombus composition in acute ischemic stroke with large vessel occlusion: impact of r-tPA treatment.

Changzhi Zhao, Guofang Chen, Zhiliang Guo, Sha Chen, Lei Ping, Qiao Li, Xiaoying Zhang, Manhua Ding, Yang Zhang

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Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Changzhi Zhao *Department of Neurosurgery, Xuzhou Central Hospital, Southeast University Affiliated Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou, China.
Guofang Chen *Department of Neurology, Xuzhou Central Hospital, Southeast University Affiliated Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou, China.
Zhiliang Guo *Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Sha ChenDepartment of Neurosurgery, Xuzhou Central Hospital, Southeast University Affiliated Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou, China.
Lei PingDepartment of Neurology, Xuzhou Central Hospital, Southeast University Affiliated Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou, China.
Qiao LiDepartment of Neurology, Xuzhou Central Hospital, Southeast University Affiliated Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou, China.
Xiaoying ZhangDepartment of Neurology, Xuzhou Central Hospital, Southeast University Affiliated Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou, China.
Manhua DingDepartment of Radiotherapy, Xuzhou Cancer Hospital, Xuzhou, China.
Yang ZhangDepartment of Neurology, Xuzhou Central Hospital, Southeast University Affiliated Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University, Xuzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Mechanical thrombectomy advances enable detection of thrombus composition changes post-intravenous thrombolysis, but evidence remains limited. This study retrospectively analyzed thrombi obtained from mechanical thrombectomy in patients with acute ischemic stroke to explore the impact of intravenous thrombolysis (IVT) on the composition of thrombi in patients with different TOAST classifications and the association between changes in thrombus components and clinical outcome data. Materials and methods: Thrombus samples from 141 patients undergoing mechanical thrombectomy ( Results: No significant baseline differences ( Conclusion: This study quantified the thrombus components of different etiologies and found that IVT could reduce the FIB content in thrombi of large artery occlusion cerebral infarction, especially in the LAA type. The platelet content in the LAA type was higher than that in the CE and the SUE types. The FIB level in the SUE type was higher than that in the CE type. FIB was not only present in the PLT area but also in the RBC area. IVT may improve thrombectomy success by disrupting thrombus structure, but it can increase fragment embolization and prolong procedure time.

Indexed as

ischemic strokemechanical thrombectomythrombolysisthrombusTOAST classification

Identifiers

PMID41357834
PMCPMC12679381

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