Evidence map›Paper›PMID 41357812›Full record

ArticlePathology oncology research : POR2025

Valosin containing protein (VCP/p97) expression in laryngeal squamous cell carcinoma: clinical evaluation and implications for targeted therapy.

Inga M C Seuthe, Hanna C Hunsicker-Biederbeck, Markus Ruwe, Julius Knierer, Eric Ehrke-Schulz, Eren Erdogan, Sabine Eichhorn, Jonas J-H Park

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Article in Pathology oncology research : POR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Inga M C SeutheDepartment of Otorhinolaryngology, Head and Neck Surgery, Catholic Hospital Hagen, University of Witten/Herdecke, Hagen, Germany.
Hanna C Hunsicker-BiederbeckDepartment of Otorhinolaryngology, Head and Neck Surgery, Catholic Hospital Hagen, University of Witten/Herdecke, Hagen, Germany.
Markus RuweInstitute for Pathology Hagen, Hagen, Germany.
Julius KniererDepartment of Otorhinolaryngology, Head and Neck Surgery, Catholic Hospital Hagen, University of Witten/Herdecke, Hagen, Germany.
Eric Ehrke-SchulzDepartment of Human Medicine, Faculty of Health, Center of Biomedical Education and Research (ZBAF), Institute for Virology and Microbiology, University of Witten/Herdecke, Witten, Germany.
Eren ErdoganDepartment of Otorhinolaryngology, Head and Neck Surgery, Catholic Hospital Hagen, University of Witten/Herdecke, Hagen, Germany.
Sabine EichhornDepartment of Otorhinolaryngology, Head and Neck Surgery, Catholic Hospital Hagen, University of Witten/Herdecke, Hagen, Germany.
Jonas J-H ParkDepartment of Otorhinolaryngology, Head and Neck Surgery, Catholic Hospital Hagen, University of Witten/Herdecke, Hagen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Valosin-containing protein (VCP/p97) is a key regulator of proteostasis and cellular stress response and has been linked to tumor progression and poor prognosis in various malignant diseases. However, data on its role in laryngeal squamous cell carcinoma (LSCC) are lacking. Methods: In this retrospective single-center study, VCP/p97 protein expression was analyzed by immunohistochemistry in a cohort of 100 LSCC patients. Expression levels were semi-quantitatively assessed with H-Score, compared to normal tissue if possible and correlated with clinicopathological parameters. Survival analyses were evaluated by Cox regression. Results: VCP/p97 was expressed in all tumors. Most LSCC (77.0%) showed a uniform staining pattern. 46 of these tumors (59.7%) exhibited a staining intensity of 2-3. Among the tumors with a non-homogeneous staining pattern (n = 23), two tumors showed a predominance to lower staining (staining intensity 1). In 13 samples a comparison to normal epithelium was possible. In these samples, 9 (69.2%) samples showed higher VCP/p97 expression compared to the normal epithelium and 4 (30.8%) showed lower expression. VCP/p97 H-Score was not significantly associated with tumor stage, grade, lymph node status or patient survival. Conclusion: Although VCP/p97 expression is not prognostic in LSCC, its consistent expression may suggest a potential role as a molecular target. Further functional and translational studies are warranted to explore the therapeutic utility of VCP/p97 inhibition in LSCC.

Indexed as

Biomarkers, TumorCarcinoma, Squamous CellLaryngeal NeoplasmsValosin Containing ProteinAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesSurvival RateBiomarkers, TumorValosin Containing ProteinVCP protein, humanHNSCCLSCCp97target therapyVCP

Identifiers

PMID41357812
PMCPMC12679038

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