ReviewFrontiers in pediatrics2025
Overnight extubation and risk of extubation failure in patients in the pediatric intensive care unit: an exploratory review.
Review in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/objectives: Extubation in pediatric intensive care units (PICUs) requires care and thoroughness to minimize risks of extubation failure, systemic complications, and mortality. Up to 20% of patients in the PICU experience extubation failure, resulting in reintubation, longer hospital stays, and higher healthcare costs. Currently, no reviews have synthesized findings on the effect of overnight extubation and its association with extubation failure. Methods: This exploratory review was conducted based on the Joanna Briggs Institute methodology and PRISMA extension for scoping reviews guidelines. We analyzed studies collected from databases such as PubMed, Scopus, Web of Science, Science Direct, VHL Regional Portal, and Google Scholar using MeSH terms, Boolean operators, and a search strategy based on population, concept, and context (PCC). Studies that evaluated the impact of overnight extubation in the PICU were included, with the primary outcome being the association with the risk of extubation failure. Results: T Results: of 275 records identified, five studies met the inclusion criteria. Four studies found no significant association between overnight extubation and extubation failure, whereas one study with a larger sample reported a higher risk of reintubation during nighttime extubation. Overall, the findings revealed heterogeneous results influenced by population type, clinical context, and organizational factors. Conclusions: The available evidence does not consistently demonstrate that overnight extubation increases the risk of failure; however, some studies suggest that patient complexity and contextual factors may modify this relationship. Therefore, extubation decisions should be individualized according to clinical stability and available resources rather than based solely on the time of day, underscoring the need for prospective and standardized studies in this field.
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