ArticleFrontiers in pediatrics2025
Dose-response relationship between oxytocin exposure during labor induction and neonatal hyperbilirubinemia.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aims to investigate the association between maternal oxytocin dosage and the risk of neonatal hyperbilirubinemia. Methods: A total of 500 mothers and their neonates were retrospectively included. Based on the cumulative oxytocin dose, participants were divided into a low-dose group ( Results: The overall incidence of neonatal hyperbilirubinemia was 10% (50/500), with rates of 2.98%, 8.98%, and 18.18% in the low-, moderate-, and high-dose oxytocin groups, respectively. High-dose oxytocin significantly increased the risk of neonatal hyperbilirubinemia (odds ratio [OR] 7.933, 95% confidence interval [CI] 2.923-21.527, Conclusion: Increased oxytocin dosage during labor induction is significantly associated with a higher risk of neonatal hyperbilirubinemia. Clinicians should be alert to the potential risk of bilirubin elevation in neonates exposed to high-dose oxytocin.
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