ArticleFrontiers in pediatrics2025
Longitudinal study on ultrasound assessment of peripheral arterial elasticity and liver stiffness for evaluating clinical intervention efficacy in children with obesity.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate the efficacy of a multidisciplinary clinical intervention in children with obesity by longitudinally monitoring changes in vascular elasticity and liver stiffness via ultrasound-derived parameters. Methods: A single-center longitudinal study was conducted on 120 children with obesity (aged 7-14 years, BMI ≥95th percentile). The participants underwent a 12-month intervention involving personalized low-calorie diets, structured aerobic exercise, and family-based cognitive-behavioral therapy. Vascular parameters (carotid intima-media thickness [IMT], flow-mediated dilation [FMD], elasticity coefficient [Ep], stiffness index [β], distensibility coefficient [CD], arterial compliance [AC]) and liver stiffness [shear wave velocity (SWV)] were assessed at baseline (T0), 6 months (T1), and 12 months (T2) via Siemens S2000 ultrasound with ARFI technology. Statistical analyses included repeated-measures ANOVA, Pearson correlation, and multivariate linear regression. Results: Significant improvements were observed in FMD (7.1%-9.5%, Conclusion: Ultrasound-based multiparameter assessment effectively quantifies improvements in vascular and hepatic function following clinical intervention in children with obesity.
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