Evidence map›Paper›PMID 41357797›Full record

ArticleFrontiers in pediatrics2025

Channel selection of metagenomic next-generation sequencing in infants pathogen detection: a multicenter cross-sectional study.

Chengcheng Yang, Minxu Li, Shumei Yang, Jianer Pan, Yue Ding, Jie Yang

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PubMed Full text at PMC Publisher
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Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Chengcheng Yang *Department of Neonatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Minxu Li *Department of Neonatology, Dongguan Women and Children Hospital, Dongguan, Guangdong, China.
Shumei Yang *Department of Neonatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jianer PanDepartment of Neonatology, Jiangmen Women and Children Hospital, Jiangmen, Guangdong, China.
Yue DingDepartment of Neonatology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jie YangDepartment of Neonatology, Guangdong Women and Children Hospital, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the neonatal period, infectious diseases associated with high morbidity (e.g., neonatal sepsis and meningitis) are preliminarily assessed using indicators like C-reactive protein (CRP) and procalcitonin, but definitive diagnosis relies on pathogen detection through methods such as blood culture, which is time-consuming and has low sensitivity. To improve diagnostic efficiency, metagenomic next-generation sequencing (mNGS) is increasingly utilized, offering three testing modalities: DNA-only, RNA-only, and combined DNA+RNA channels. This retrospective study analyzed 894 clinical samples (peripheral blood, sputum, bronchoalveolar lavage fluid) to compare detection rates across channels. The overall mNGS positivity rate was 51.9% (464/894), with no significant differences among DNA-only (50.8%), RNA-only (55.7%), and combined channels (49.6%) (

Indexed as

channelinfectious diseasesMNGsneonatepathogene

Identifiers

PMID41357797
PMCPMC12678369

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.