ReviewFrontiers in pediatrics2025
Exploring diversity: a review of animal models for investigating variations in sex characteristics.
Review in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Burden of Liver Disease Among Individuals With Turner Syndrome and Klinefelter Syndrome: A Comprehensive Perspective.Chronic diseases and translational medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
This review examines mechanisms across various organisms to enhance comprehension of Variations in Sex Characteristics (VSCs) and suggests suitable models for investigation. VSCs are the result of a collection of congenital conditions characterized by atypical development of both internal and external reproductive structures. These conditions may arise from variations in genes, developmental processes, and hormonal influences. Animal models are crucial for studying VSCs due to their ability to provide valuable insights into the underlying mechanisms in which sexual differentiation exists. Comparative research across species has further emphasized the nature of certain sex-determining genes and pathways, providing a broader understanding of the evolutionary conservation of sexual differentiation mechanisms. By integrating findings from diverse animal models, encompassing the genetic, molecular, and comparative perspective, this review seeks to provide a cohesive understanding of the complex processes underlying VSCs in animals, with implications for translational research and potential treatments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.