ArticleFrontiers in veterinary science2025
Effects of
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The juvenile period represents a critical rearing phase in animals, during which rearing quality directly impacts adult productive performance. Plant extracts have been used as feed additives to promote growth, inhibit bacteria, enhance immunity, improve animal health, and ensure the safety of animal products. Therefore, our study aimed to investigate the effects of Methods: Forty-eight newborn calves were randomly allocated to four groups (12 calves/group) and fed milk replacer supplemented with 0 mg (control, CON), 400 mg (Group A), 800 mg (Group B), or 1,200 mg (Group C) of EHE. Body weight and serum biomarkers were measured on d 30 and 60. Network pharmacology was employed to identify EHE-related antioxidant targets, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. Results: Calves in group C exhibited significantly higher average daily gain (ADG) compared with CON during d 30-60. Both dry matter intake (DMI) and ADG across treatment groups demonstrated a dose-dependent increase. Serum growth hormone (GH) shows the same trend as daily weight gain and feed intake. Serum analysis revealed that superoxide dismutase (SOD) activity in group C was significantly elevated versus CON, Network pharmacology identified 150 potential antioxidant targets of EHE, primarily enriched in pathways associated with cancer, hepatic injury, apoptosis, and viral infection, suggesting immune-modulatory effects. Discussion: Based on these findings, it can be inferred that supplementing milk replacer with EHE enhances calf growth performance, regulating oxidative stress, and it regulates signaling pathways related to immune response and apoptosis through interactions with key targets such as IL6, TP53, MAPK1, AKT1, TNF, BCL2, and ESR1.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.