Evidence map›Paper›PMID 41357745›Full record

ArticleScientifica2025

Antidepressant-Like Effect of an Immediate-Release Formulation of

Zakaria Abdullah Ibrahim, Ofosua Adi-Dako, Kevin Kofi Adutwum-Ofosu, Patrick Amoateng, Frimpong Appiah, Awo Efua Koomson, Donatus Wewura Adongo, Awo Afi Kwapong, Kennedy Kwami Edem Kukuia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientifica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zakaria Abdullah IbrahimDepartment of Medical Pharmacology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.
Ofosua Adi-DakoDepartment of Pharmaceutics and Microbiology, School of Pharmacy, College of Health Sciences, University of Ghana, Accra, Ghana.ORCID https://orcid.org/0000-0002-5166-2042
Kevin Kofi Adutwum-OfosuDepartment of Anatomy, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.
Patrick AmoatengDepartment of Pharmacology and Toxicology, School of Pharmacy, College of Health Sciences, University of Ghana, Accra, Ghana.ORCID https://orcid.org/0000-0002-3607-6870
Frimpong AppiahDepartment of Community Health and Medicine, School of Food and Health Sciences, Anglican University College of Technology, Nkoranza, Ghana.
Awo Efua KoomsonDepartment of Medical Pharmacology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.
Donatus Wewura AdongoDepartment of Pharmacology, School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana.
Awo Afi KwapongDepartment of Pharmaceutics and Microbiology, School of Pharmacy, College of Health Sciences, University of Ghana, Accra, Ghana.ORCID https://orcid.org/0000-0002-7613-3454
Kennedy Kwami Edem KukuiaDepartment of Medical Pharmacology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.ORCID https://orcid.org/0000-0003-2948-9615

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Antidepressant-like effects of the crude extract of Methods: Using the wet granulation method, MOE was formulated into immediate-release dosage forms (MOE-IR F Results: MOE-IR F Conclusion: Collectively, MOE-IR demonstrated antidepressant-like that may be associated with antioxidant effects, decreased plasma corticosterone levels, and increased DG dendritic spine density.

Indexed as

brain-derived neurotrophic factorchronic unpredictable mild stressforced swim testimmediate-release formulationMallotus oppositifoliustail suspension test

Identifiers

PMID41357745
PMCPMC12681405

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.