Evidence map›Paper›PMID 41357693›Full record

ArticleIranian journal of public health2025

Causal Relationship between Immune Cells and Postpartum Depression: A Bidirectional Two-Sample Mendelian Randomization Study.

Yingjia Zhu, Feng Cheng, Wenhui Wang, Xinyun Yang, Mingjie He, Zhiyin Zhang, Linling Zhu

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Article in Iranian journal of public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yingjia ZhuDepartment of Gynecology, Hangzhou Women's Hospital, Hangzhou, Zhejiang, 310000, China.
Feng ChengDepartment of Orthopedics, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, 310000, China.
Wenhui WangDepartment of Pathology, Hangzhou Women's Hospital, Hangzhou, Zhejiang, 310000, China.
Xinyun YangDepartment of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, China.
Mingjie HeDepartment of General Practice, Yiqiao Community Health Service Center, Hangzhou, Zhejiang 310000, China.
Zhiyin ZhangDepartment of Gynecology, Hangzhou Women's Hospital, Hangzhou, Zhejiang, 310000, China.
Linling ZhuDepartment of Gynecology, Hangzhou Women's Hospital, Hangzhou, Zhejiang, 310000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Postpartum depression (PPD) is influenced by immune factors, particularly immune cells. The causal relationship between these cells and PPD is unclear. Methods: Bidirectional two-sample Mendelian randomization (TSMR) analysis was performed to determine the causal relationship between immune cell characteristics and PPD. The main analysis method used was the inverse variance weighted (IVW) method. To ensure the robustness, heterogeneity, and horizontal pleiotropy of the results, a comprehensive sensitivity analysis was conducted. Results: Overall, 28 immune cell phenotypes were identified as causally related to the onset of PPD. Most of them were distributed in the B cell group and the Treg cell group. Further analysis revealed that 13 types of immune cells had a promoting effect on PPD, whereas 15 types of immune cells had a protective effect. In addition, the incidence of PPD was found to be causally related to CD62L on granulocyte [IVW: OR (95%): 1.183 (1.037 to 1.348), P = 0.012]. Conclusion: The study unveils the causal link between immune cells and susceptibility to postpartum depression from a genetic standpoint, providing new directions for drug development and precision medicine for PPD treatment.

Indexed as

Causal inferenceGenetic variationImmune cellsMendelian randomizationPostpartum depression

Identifiers

PMID41357693
PMCPMC12676064

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