ArticleWorld journal of gastrointestinal surgery2025
Predictive value of systemic immune-inflammation index and serum lactoferrin for postoperative survival in older patients with colon cancer.
Article in World journal of gastrointestinal surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- From inflammation to precision medicine in colon cancer: Methodological considerations and future directions.World journal of gastrointestinal surgery · 2026Article
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Abstract
backgroundSystemic immune-inflammation index (SII) combined with serum lactoferrin (LF) level can provide a reference for predicting the postoperative survival and prognosis of older patients with colon cancer.
aimTo evaluate the predictive value of SII combined with serum LF for postoperative survival in older patients with colon cancer.
methodsThis prospective study included 62 older patients [range, 65-85 years; average age (72.46 ± 6.02) years] with colon cancer who underwent radical surgery at our hospital between January 2023 and September 2024. Colon cancer was confirmed on postoperative pathology. All patients underwent peripheral blood, LF, and tumor marker tests and imaging examinations preoperatively. The ability to predict overall survival (OS) and disease-free survival (DFS) by dynamically monitoring the SII [platelet (PLT) count × neutrophil (NEU) count/lymphocyte (LYM) count] and LF levels in combination with postoperative follow-up data was assessed. SII, LF levels, and postoperative data were analyzed using receiver operating characteristic curves, univariate, and multivariate Cox regression analyses to assess OS and DFS.
resultsAll patients were followed up conventionally postoperatively. There were no significant differences in the patients' baseline data. From 3 months preoperatively until after surgery, the values of routine blood indices (NEUs, LYMs, and PLTs) and SII tended to decrease, but the difference was not statistically significant. The LF level gradually decreased, and there were significant differences at 1 week, 1 month and 3 months postoperatively (
conclusionThis preliminary analysis suggests that the SII and LF levels may predict the survival and prognosis of older patients with colon cancer postoperatively, when assessing the risk of postoperative recurrence and complications. These two categories of indicators have good prognostic evaluation potential in clinical practice and can provide strong support for the development of individualized treatment strategies.
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