ArticleWorld journal of gastrointestinal surgery2025
Preoperative malignancy risk assessment in pancreatic cystic neoplasms using clinical and laboratory parameters.
Article in World journal of gastrointestinal surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Age and red cell distribution width in pancreatic cystic neoplasms: A simple tool for preoperative malignancy risk stratification.World journal of gastrointestinal surgery · 2026Article
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7 authors.
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Abstract
backgroundPancreatic cystic neoplasms (PCNs) are increasingly detected due to advancements in radiographic techniques, with a prevalence of approximately 15% in the general population. These lesions range from benign to premalignant and malignant, posing a diagnostic challenge. Accurate differentiation is critical, as premalignant and malignant PCNs often require surgical intervention, while benign cysts may only need monitoring unless symptomatic. Current diagnostic methods, including cross-sectional imaging, endoscopic ultrasonography, and endoscopic ultrasonography-guided fine-needle aspiration/biopsy, are specialized, not universally available, and have variable accuracy. Clinical and laboratory parameters such as carbohydrate antigen 19-9 (CA 19-9), neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and red cell distribution width (RDW) have been associated with malignancy risk, though only CA 19-9 is guideline-supported.
aimTo assess the malignancy risk of PCNs using preoperative clinical and routine laboratory parameters.
methodsA retrospective cohort study analyzed 70 patients who underwent surgery for PCNs at Ankara Bilkent City Hospital between February 2019 and March 2023. Patients were categorized into group A (benign or low-grade dysplasia,
resultsGroup B patients were older (69.86 ± 9.58 years
conclusionAge and RDW are independent predictors of malignancy in PCNs, aiding in patient selection for advanced diagnostics and surgery. Larger, multicenter studies are needed to validate these findings.
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