ReviewFrontiers in oncology2025
Pediatric tumor microenvironment: developmental dynamics and therapy resistance.
Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tumor microenvironment (TME) in pediatric cancers is profoundly shaped by the unique biological context of childhood development. Unlike adult tumors, pediatric malignancies arise in growing tissues, where evolving immune systems, dynamic stromal elements, and distinct hormonal and microbial influences converge to create highly specialized tumor-supportive niches. This review explores how developmental processes interact with tumor biology to drive immune evasion, therapy resistance, and disease progression. Key mechanisms such as extracellular matrix remodeling, metabolic reprogramming, and epigenetic plasticity are highlighted as critical contributors to treatment failure. Also, the recent advancements in nanomedicine, circulating markers makes it possible for interventions to be more precise and age-informed. The integration of developmental biology along with tumor ecosystem can emphasis the necessity of developing treatment plans that take into account risks and advantages associated with pediatric TME.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.