SynthesisFrontiers in oncology2025
Association between hysterectomy for benign indications and the risk of breast cancer: a systematic review and meta- analysis.
Synthesis in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To determine the association between hysterectomy performed for benign indications and the risk of developing BC. Methods: A literature search was conducted in PubMed, Embase, and the Cochrane Library from database inception up to December 11, 2024. Eligible studies were observational design. Relative ratios (RRs) and 95% confidence intervals (CIs) were pooled using a random-effects model, Results: This meta-analysis included 12 studies, consisting of 4 case-control studies and 8 cohort studies. The pooled analysis of case-control studies indicated that hysterectomy reduced the risk of BC (RR = 0.839, 95% CI: 0.707-0.995, Conclusions: The present study reveals a protective effect of hysterectomy on the occurrence of BC in case-control studies. However, more studies, especially cohort studies, are needed to elucidate the potential beneficial effects of hysterectomy on the development of BC. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024596235, identifier CRD42024612164.
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