ArticleFrontiers in oncology2025
Pan-cancer analysis reveals ELFN1 as a novel prognostic biomarker and immunotherapeutic target associated with tumor microenvironment remodeling and promoting malignant phenotypes in colorectal cancer.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Extracellular leucine rich repeat and fibronectin type III domain containing 1 (ELFN1), a transmembrane protein implicated in tumorigenesis and therapy resistance, remains mechanistically undefined as a pan-cancer target. In this study, we aimed to elucidate the function and potential mechanism of action of ELFN1 across cancers. Methods: Through integrative analysis of TCGA and GTEx datasets, we systematically characterized ELFN1 across 33 cancer types, including its expression patterns, prognostic value, mutation landscape, methylation modifications, protein-protein interaction (PPI) networks, and the relationship between ELFN1 expression and immune infiltration. KEGG enrichment analysis was also performed to predict the functions and associated cellular pathways of ELFN1. In addition, the molecular docking tool was used to analyze the affinities between ELFN1 protein and drugs. Finally, we assessed the effect of ELFN1 knockdown on colorectal cancer (CRC) cells using Results: Our study revealed significant dysregulation of ELFN1 across various cancer types, with notable diagnostic and prognostic utility in most cancers analyzed. Mechanistically, ELFN1 expression was associated with DNA methylation, DNA repair, genomic instability, and tumor microenvironment (TME) scores in multiple cancer types. Furthermore, Drug sensitivity profiling linked ELFN1 to ABT-737 susceptibility and benzaldehyde resistance through molecular docking. In CRC cells, ELFN1 knockdown significantly inhibited tumor proliferation, migration, and motility. Conclusion: The expression level of ELFN1 may provide insights into tumor development and progression in multiple cancers, including CRC, highlighting its potential utility as an effective prognostic biomarkers and immunotherapeutic targets.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.