SynthesisFrontiers in medicine2025
Fire needling therapy for neurodermatitis: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Transcriptomic responses of skin to different micro-injury modalities: fire filiform needling, ablative fractional COLasers in medical science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This meta-analysis aimed to evaluate the clinical effectiveness and safety of fire needling therapy for neurodermatitis, either as monotherapy or in combination with conventional treatments. Methods: Following PRISMA 2020 guidelines, randomized controlled trials were systematically searched across Chinese and English databases up to October 2024. Ten RCTs involving 868 patients were included. Outcomes assessed included effectiveness rate, recurrence rate, pruritus scores, inflammatory cytokine levels, Dermatology Life Quality Index (DLQI), and adverse events. Data were analyzed using RevMan 5.4.1, with effect sizes expressed as risk ratios or mean differences. Results: Fire needling monotherapy showed no significant superiority over conventional treatment in effectiveness rates ( Conclusion: Fire needling therapy combined with conventional treatment may enhance therapeutic outcomes for neurodermatitis, particularly in reducing pruritus, improving quality of life, and modulating inflammation. However, limitations include methodological flaws in included studies and regional publication bias. Higher-quality RCTs are needed to validate these findings and clarify long-term effectiveness. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024617150, identifier CRD42024617150.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.