ArticleWorld journal of transplantation2025
Hyper-reduced grafts in living donor liver transplant: Techniques and outcomes.
Article in World journal of transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Safe and Early Primary Closure of Open Abdomen in Pediatric Liver Transplantation Using a Doppler-Guided Tension Relief Strategy and Enhanced Wound Environment.Journal of transplantation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPediatric liver transplantation (LT) is the definitive treatment for end-stage liver disease and acute liver failure in children. However, graft size mismatch poses significant challenges, particularly in infants weighing less than 10 kg. Large-for-size grafts can lead to severe complications, including vascular thrombosis and impaired graft perfusion. Surgical innovations, such as hyper-reduced left lateral segment (HRLLS) grafts and monosegmental grafts (MSG), offer viable solutions by tailoring graft size without compromising vascular or biliary integrity.
aimTo analyze the techniques and outcomes of HRLLS and MSG grafts in pediatric liver trabsplantation.
methodsFollowing Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a comprehensive literature search was conducted across PubMed, Scopus, and Google Scholar, including studies up to February 2025. Eligible studies included case-control, observational, and randomized controlled trials reporting clinical outcomes of HRLLS, MSG, or reduced left lateral segment grafts (RLLS) in pediatric LT. The Joanna Briggs Institute Critical Appraisal Checklist was used for quality assessment. Meta-analysis was performed using MetaXL software to pool survival outcomes and assess complication profiles.
resultsEighteen studies involving various graft reduction techniques were included. Both HRLLS and MSG demonstrated comparable one-year survival rates exceeding 80%, with some studies reporting rates above 95%. Complications such as hepatic artery thrombosis, portal vein thrombosis, and sepsis were slightly more frequent in HRLLS/RLLS recipients but remained within acceptable limits. Meta-analysis revealed no significant differences in survivability between graft types.
conclusionHRLLS and MSG techniques enable successful liver transplantation in small pediatric recipients, achieving long-term outcomes comparable to standard approaches. These graft modification strategies expand donor pool utilization and optimize patient survival while mitigating large-for-size complications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.