Evidence map›Paper›PMID 41357384›Full record

ArticleWorld journal of transplantation2025

Increased mortality when combining older donors and recipients in heart transplantation.

Martin Geard Walsh, Ervin Y Cui, Divyaam Satija, Doug A Gouchoe, Matthew C Henn, Asvin M Ganapathi, Bryan A Whitson, Kukbin Choi

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Article in World journal of transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Martin Geard WalshDepartment of Surgery, Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43201, United States.
Ervin Y CuiCOPPER Laboratory, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43201, United States.
Divyaam SatijaDepartment of Surgery, Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43201, United States.
Doug A GouchoeDepartment of Surgery, Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43201, United States.
Matthew C HennDepartment of Surgery, Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43201, United States.
Asvin M GanapathiDivision of Cardiac Surgery, Los Robles Regional Medical Center, Thousand Oaks, CA 91360, United States.
Bryan A WhitsonDepartment of Surgery, Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43201, United States.
Kukbin ChoiDepartment of Surgery, Division of Cardiac Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43201, United States. kukbin.choi@osumc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe utilization of hearts from older donors has increased, particularly for older recipients. However, the impact of older donor hearts on recipients of different ages is less known.

aimTo determine the impact of older donor hearts on post-transplant outcomes across different recipient age groups.

methodsThe Organ Procurement and Transplant Network database was queried from 2006 to March 2024. Four groups were created stratifying by donor age (> 55 years) and recipient age (> 60 years). Kaplan-Meier curves and Cox regression models were used.

resultsOne thousand fifty out of 39868 transplants (2.6%) were performed utilizing hearts from older donors. The rate of older donor hearts in younger recipients was only 1.8%, while the older donor hearts were used 4.0% in older recipients (

conclusionThis study demonstrates the higher utilization of older donor hearts (aged more than 55) in older recipients. Paradoxically, the combination of older donor hearts with older recipients is associated with a higher risk of mortality. However, these organs remain valuable options across all recipient age groups in current context of organ shortage.

Indexed as

Donor ageHeart failureHeart transplantationMortalityRecipient ageSurgical outcomes

Identifiers

PMID41357384
PMCPMC12679219

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