ArticleWorld journal of transplantation2025
Increased risk of rejection in liver transplant recipients with a history of malabsorptive bariatric surgery.
Article in World journal of transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Beyond Weight Reduction: An Updated Systematic Review and Meta-Analysis of Metabolic Syndrome Components and Metabolic Dysfunction-Associated Steatotic Liver Disease Outcomes After Endoscopic Sleeve Gastroplasty.Journal of clinical medicine · 2026Review
- Navigating liver transplantation after malabsorptive bariatric surgery: A new risk of rejection.World journal of transplantation · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalabsorptive bariatric surgery, including Roux-en-Y gastric bypass and duodenal switch, are known to be more metabolically effective than restrictive surgery. However, the permanent alteration of gastrointestinal anatomy from these operations has been shown to alter the kinetics of drug absorption and may make subsequent surgeries more technically challenging.
aimTo evaluate perioperative liver transplant outcomes and rates of acute cellular rejection in recipients with prior malabsorptive bariatric surgery.
methodsPatients who underwent liver transplantation at a single institution between 2005-2024 with a history of malabsorptive bariatric surgery were identified. Matched controls were selected based on age, sex, listing model for end-stage liver disease (MELD), and primary liver diagnosis.
resultsA total of 12 liver transplant patients with prior malabsorptive surgery and 25 controls were included. The mean age in the malabsorptive group was 50.5 years at the time of transplant and 92% were female. The mean MELD at the time of transplant was 27.6 and mean body mass index was 28. There were no significant differences in length of stay, post operative complications, or 1 year survival between the controls and malabsorptive patients. However, the malabsorptive group was significantly more likely to experience biopsy-proven and clinically treated acute cellular rejection than the controls (24%
conclusionPrevious malabsorptive bariatric surgery in liver transplant recipients did not increase the risk of perioperative complications or mortality but significantly increased the rate and frequency of acute cellular rejection.
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