Evidence map›Paper›PMID 41357341›Full record

ReviewEClinicalMedicine2025

Landscape of paediatric oncology clinical trials in Asia.

Muhammad Saghir Khan, Daisuke Tomizawa, Huyung Zheng, Vaskar Saha, Hany Ariffin, Hiroki Hori, Ramandeep Singh Arora, Gevorg Tamamyan, Mururul Aisyi, Purna Kurkure and 16 more

Abstract readReview
In one paragraph

Review in EClinicalMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Muhammad Saghir KhanDepartment of Pediatrics, King Faisal Specialist Hospital and Research Center, Al-Madinah Al-Munawarrah, Saudi Arabia.
Daisuke TomizawaDivision of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Huyung ZhengHematology Center, National Key Discipline of Pediatric Hematology, National Key Discipline of Pediatrics (Capital Medical University); Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
Vaskar SahaTata Translational Cancer Research Centre, Tata Medical Center, Kolkata, India.
Hany AriffinDepartment of Paediatrics, Universiti Malaya, Kuala Lumpur, Malaysia.
Hiroki HoriAsian Pediatric Hematology and Oncology Group.
Ramandeep Singh AroraAsian Pediatric Hematology and Oncology Group.
Gevorg TamamyanAsian Pediatric Hematology and Oncology Group.
Mururul AisyiDepartment of Paediatric Haematology Oncology, Indonesian National Cancer Center, Dharmais Cancer Hospital, Jakarta, Indonesia.
Purna KurkureAsian Pediatric Hematology and Oncology Group.
Bharat AgarwalAsian Pediatric Hematology and Oncology Group.
Alice L YuAsian Pediatric Hematology and Oncology Group.
Rashmi DalviAsian Pediatric Hematology and Oncology Group.
Kirill KirgizovAsian Pediatric Hematology and Oncology Group.
Bow Wen ChenAsian Pediatric Hematology and Oncology Group.
Panya SeksarnAsian Pediatric Hematology and Oncology Group.
Akira NakagawaraAsian Pediatric Hematology and Oncology Group.
Godfrey C F ChanAsian Pediatric Hematology and Oncology Group.
Ayumu ArakawaDepartment of Pediatric Oncology, National Cancer Center Hospital, Tokyo, Japan.
Yijin GaoDepartment of Oncology, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Shekhar KrishnanTata Translational Cancer Research Centre, Tata Medical Center, Kolkata, India.
Allen E J YeohDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Xue-Qun LuoDepartment of Pediatrics, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Xiao-Fan ZhuDepartment of Pediatric, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
Atsushi ManabeAsian Pediatric Hematology and Oncology Group.
Chi-Kong LiAsian Pediatric Hematology and Oncology Group.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this second paper of a Series on childhood cancer in Asia, we provide an overview on the Paediatric Oncology Clinical Trials in Asia. Asia with a population of 4.7 billion constitutes about 60% of the world's population. The continent accounts for about half of the global paediatric cancer burden. Many Asian countries have consequently formed national professional societies in childhood cancer. Multicentre clinical trials are pivotal in advancing survival outcomes in paediatric oncology. The continent's diverse socioeconomic conditions may account for significant disparities in the development of such trials. However some countries with good financial resources are relatively deficient in developing clinical trials. In general, the countries show three distinct levels of clinical trials development: established, emerging and nascent. This article reports the landscape of multicentre clinical trials in Asia and the hurdles that clinicians face to actively engage in quality research and clinical trials. Although a 'one-size-fits-all' approach is not feasible, the successful development of clinical trials systems in some countries can offer valuable lessons and insights for others. This is the second in a

Indexed as

AsiaChallengesChildhood cancerClinical trialsMulticentre

Identifiers

PMID41357341
PMCPMC12675019

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.