ArticleEClinicalMedicine2025
Measles seropositivity in previously vaccinated individuals: a systematic review and meta-analysis.
Article in EClinicalMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Measles Seroprevalence Among Healthcare Workers in a Tertiary Hospital in Central Greece, 2017.Vaccines · 2026Article
- Decreasing Antibody Titers and the Slow Decay of Measles Immunity in Mexico's Current Epidemiological Landscape.Vaccines · 2026Article
- Waning of vaccine-induced measles antibodies and population immunity gaps in the post-elimination era: a multicenter seroepidemiological study in China.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Background: With the resurgence of measles outbreaks globally it is important to understand how seropositivity induced by measles vaccination wanes over time. We aimed to measure the prevalence of measles seropositivity in vaccinated individuals and assess changes in antibody levels over time since vaccination. Methods: We conducted a systematic review and meta-analysis by searching PubMed, Embase, Scopus, Web of Science, and Cochrane Library databases from January 1980 to April 2025 for studies reporting serological outcomes following measles-containing vaccination. The search criteria included clinical trials, cross-sectional studies, cohort studies, and case series with ≥10 participants. The primary outcome was the proportion of vaccinated individuals seropositive for measles IgG antibodies. Meta-regression was performed to assess the relationship between seropositivity and time since vaccination. The study was registered with PROSPERO, CRD420251026672. Findings: The search identified 2348 unique records. Following title and abstract screening, 89 articles were selected for full-text review, of which 18 studies were included, encompassing 23,236 vaccinated individuals from 10 countries. Overall pooled proportion of seropositive individuals was 87·8% (95% Confidence Interval [CI] 83·9%-91·2%, I Interpretation: Ten years after measles vaccination, vaccinated individuals displayed high seropositivity. The observed decrease in measles seropositivity in the years after vaccination may indicate waning humoral immunity. However, this systematic review and meta-analysis was unable to assess the relationship between seropositivity and measles infection rates, thus further investigation is needed. Funding: No funding was received for the study design, data collection, analysis, interpretation, writing of the manuscript, or the decision to submit for publication.
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