Evidence map›Paper›PMID 41357335›Full record

ArticleEClinicalMedicine2025

Metacognitive therapy and work-focus for patients with depression, anxiety or comorbid depression and anxiety on sick leave: a single-centre, open-label randomised controlled trial.

Ragne G H Gjengedal, Marit Hannisdal, Kåre Osnes, Silje E Reme, Adrian Wells, Roland Blonk, Hilde D Lending, Sverre U Johnson, Suzanne E Lagerveld, Frederick Anyan and 8 more

Registry-linked trialAbstract read
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In one paragraph

Article in EClinicalMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03301922 (Metacognitive Therapy and Work Interventions for Patients on Sick Leave Due to Common Mental Disorders), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03301922 naunknown statusnot on this map

Metacognitive Therapy and Work Interventions for Patients on Sick Leave Due to Common Mental Disorders: A Randomized Waiting List Controlled Trial

TypeinterventionalSponsorNorwegian University of Science and TechnologyRan2017 to 2023Enrolled240ConditionsAnxiety, DepressionArmsMetacognitive therapy and work-focused interventions, Waiting list
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ragne G H GjengedalDivision of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.
Marit HannisdalDivision of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.
Kåre OsnesDivision of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.
Silje E RemeDepartment of Psychology, University of Oslo, Oslo, Norway.
Adrian WellsDivision of Psychology and Mental Health, School of Psychological Sciences, Faculty of Biology, Medicine and Health, School of Health Sciences, University of Manchester, Manchester, United Kingdom.
Roland BlonkTilburg University, Tilburg, the Netherlands.
Hilde D LendingDivision of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.
Sverre U JohnsonDepartment of Psychology, University of Oslo, Oslo, Norway.
Suzanne E LagerveldThe Dutch Institute of Employee Benefit Schemes, Amsterdam, the Netherlands.
Frederick AnyanDepartment of Psychology, Norwegian University of Science and Technology, Trondheim, Norway.
Hans M NordahlDivision of Psychiatry, Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
Romée B T W GerritsenOslo University Hospital, Oslo, Norway.
Marianne T BjørndalDivision of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.
Danielle WrightDivision of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.
Kenneth SandinThe Norwegian Psychological Association, Oslo, Norway.
Kjersti S BjøntegårdDivision of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.
Jørund SchwachDivision of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.
Odin HjemdalDepartment of Psychology, Norwegian University of Science and Technology, Trondheim, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Employment is a key determinant of health, but mental health treatments have limited success on return-to-work (RTW) in depression and anxiety. We investigated the effectiveness of metacognitive therapy combined with work-focused components (MCT + WF) to improve RTW and reduce anxiety and depression in patients on sick leave. Methods: This single-centre, open-label, randomised controlled trial was conducted at an outpatient clinic (Diakonhjemmet Hospital) in Norway. Eligible patients were adults on sick leave with depression and/or anxiety. Patients with severe mental disorder or substance abuse were excluded. Participants were randomly assigned using computer-generated block randomisation, stratified by gender and percentage of sick leave, to receive either immediate MCT + WF or delayed MCT + WF after 8-12 weeks on a waitlist. Outcome assessors were blinded. Primary outcomes were depression (BDI-II), anxiety (BAI), and RTW at 12 weeks. Sick leave data were obtained from a national registry and self-report; symptoms were self-reported. Analyses followed the intention-to-treat principle, including all randomised participants. This trial was registered with ClinicalTrials.gov, NCT03301922. Findings: Between Sept 11, 2017, and Nov 17, 2020, 236 patients were enrolled and randomly assigned to immediate MCT + WF ( Interpretation: Immediate MCT + WF significantly improved RTW and reduced symptoms of depression and anxiety compared with waiting. Generalisability may be constrained by Norway's welfare system; strengths include registry data and naturalistic outpatient setting. The favourable outcomes suggest that MCT + WF could be integrated into mental health care. Funding: The study was funded by the South-Eastern Norway Regional Health Authority and DAM foundation-Mental Health, Diakonhjemmet Hospital.

Indexed as

AnxietyDepressionMetacognitive therapySick leaveWork focus

Identifiers

PMID41357335
PMCPMC12675033

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.