ArticleBiochemistry and biophysics reports2025
Coordinated upregulation of PABPC1L and SNHG lncRNAs defines a tumor-specific expression module in colorectal cancer: evidence from paired tumor-normal expression profiling.
Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- PABPC1 in Cancer: From a Translational Housekeeper to a Stress-Responsive Regulatory Hub.Cancer science · 2026Review
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Nonsense-mediated mRNA decay (NMD) has an important role in the pathoetiology of cancer, including colorectal cancer (CRC). Identification of the lncRNAs associated with this function would enhance our understating about the molecular mechanisms of CRC and facilitate design of novel therapies. In the current study, we used a bioinformatics approach to find NMD-associated lncRNAs in CRC. Then, we assessed expression of these genes in 43 paired CRC samples and adjacent non-tumor (ANT) tissues. Three transcripts were significantly overexpressed in tumor tissue: PABPC1L (mean fold-change ≈ 5.20, 95 % CI 2.30-11.85, P = 0.0003), SNHG17 (mean fold-change ≈ 5.46, 95 % CI 2.04-14.50, P = 0.001), and SNHG1 (mean fold-change ≈ 5.82, P = 0.0086). RUSC1-AS1 showed a non-significant trend toward upregulation (fold-change ≈ 2.15, 95 % CI 0.92-5.00, P = 0.07). The combined four-gene model demonstrated moderate discriminatory power, yielding an AUC of 0.76 (95 % CI 0.65-0.86,
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