Trial reportTheScientificWorldJournal2025
Fluoride Retention in Nocturnal Salivary Sediment After Use of a 5000 ppm F Dentifrice: A Randomized Crossover Clinical Trial.
Trial report in TheScientificWorldJournal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Fluoride (F) is an essential strategy for caries control, with fluoridated dentifrices being the most effective form of its use. Studies have shown that salivary sediment retains more F than the supernatant, contributing to its maintenance in the oral environment. This study was aimed at evaluating the bioavailability of F in salivary sediment after the use of a high-F dentifrice during the nocturnal period. In this in vivo crossover study, 10 participants used a dentifrice containing 5000 ppm F and collected saliva during diurnal and nocturnal periods. These samples were analyzed to compare F concentrations in the salivary supernatant and sediment using an ion-specific electrode. A two-way ANOVA was used for statistical analysis, considering the factors "saliva compartment" and "period," with a significance level of 5%. No significant differences were observed between the two periods at baseline ( Trial Registration: Brazilian Clinical Trials Registry (REBEC) identifier: RBR-10bhvcr4.
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