ArticleFrontiers in immunology2025
Coordinated kinetics of humoral, T-cell, and cytokine responses to SARS-COV-2 in West African healthcare workers: a multicenter longitudinal study in university hospitals of Abidjan, Côte d'Ivoire.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Healthcare workers in resource-limited settings are frequently exposed to SARS-CoV-2, often with incomplete vaccine coverage. Yet, their adaptive immune responses remain poorly characterized in sub-Saharan Africa. Methods: We conducted a multicenter study involving 36 healthcare workers with RT-PCR-confirmed SARS-CoV-2 infection (83.3% vaccinated) and 40 strictly unvaccinated, COVID-19-naïve controls from three university hospitals in Abidjan. Blood samples were collected on Days 0, 7, 14, 21, and 28. IgM and IgG were measured by ELFA (Mini VIDAS Results: Infected participants showed strong antibody production at baseline. IgG levels were closely linked to neutralizing activity (ρ = 0.83; Conclusion: This cohort developed a broad immune response involving antibodies, T cells, and cytokines. The IL-17A pattern seen in asymptomatic cases may reflect effective mucosal control. These findings contribute essential data from a region where immune profiling remains limited.
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