Evidence map›Paper›PMID 41357240›Full record

ArticleFrontiers in immunology2025

Enhancement of activation-induced T cell proliferation by SIRPG in a CD47-independent manner.

Flavien Marguerie, Mohammad A Saifi, Benjamin Geary, David Barnes, Laura Lim, Anna Helena Jonsson, I-Cheng Ho

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Flavien MarguerieDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States.
Mohammad A SaifiDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States.
Benjamin GearyDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States.
David BarnesDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States.
Laura LimDivision of Rheumatology, Department of Medicine, University of Colorado, Aurora, CO, United States.
Anna Helena JonssonDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States.
I-Cheng HoDivision of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States.

Funding

Joint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4M
Research Training in Rheumatology INCLUDE Down Syndrome SupplementT32AR007534 · NIAMS · UNIVERSITY OF COLORADO DENVER · PI Kristine A. Kuhn · 1986 to 2026
$6.1M
Regulatory roles of peptidylarginine deimination in elastogenisisR01HL158601 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HO, I-CHENG · 2022 to 2025
$2.2M
Functional analysis of SIRPG, a T cell-specific autoimmune geneR21AI169191 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI HO, I-CHENG · 2022 to 2023
$492k
NHLBI NIH HHS R01 HL158601NIAID NIH HHS R21 AI169191NIAMS NIH HHS P30 AR070253NIAMS NIH HHS T32 AR007534
6 · The paper itself

Abstract

SIRPG, a primate-specific type 1 transmembrane protein in the Signal Regulatory Protein (SIRP) family, is predominantly expressed in T cells. It contains a short cytoplasmic domain, which does not contain any known signaling motif, and its only known ligand is CD47. Several genetic variations in

Indexed as

CD47 AntigenCD8-Positive T-LymphocytesLymphocyte ActivationReceptors, ImmunologicAnimalsCell ProliferationHumansCD47 AntigenCD47 protein, humanReceptors, ImmunologicCD47GZMBGZMKproliferationSIRPGT cells

Identifiers

PMID41357240
PMCPMC12678352

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.