Evidence map›Paper›PMID 41357232›Full record

ArticleFrontiers in immunology2025

Associations between gut microbiota and immune status in untreated B-cell lymphoma patients.

Jingxin Zhou, Jinrong Yao, Na Hu, Jing Su

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jingxin Zhou *Department of Hematology, Suqian First People's Hospital Suqian, Suqian, Jiangsu, China.
Jinrong Yao *Department of Hematology, Suqian First People's Hospital Suqian, Suqian, Jiangsu, China.
Na HuDepartment of Hematology, Suqian First People's Hospital Suqian, Suqian, Jiangsu, China.
Jing SuDepartment of Hematology, Suqian First People's Hospital Suqian, Suqian, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Emerging evidence links gut microbiota to tumorigenesis via immune modulation, though subtype-specific microbial signatures in B-cell lymphomas remain unclear. This study explores microbiota-immune interactions across lymphoma subtypes to inform microbiota-targeted therapies. Methods: Twenty-seven treatment-naive B-cell lymphoma patients (8 DLBCL, 5 SLL, 5 FL, 7 MZL, 2 WM) and 20 HCs were enrolled. Fecal 16S rDNA sequencing, flow cytometry for immune cell subsets, and ELISA for cytokines/immunoglobulins were performed. Microbiota differences and correlations with immune parameters were analyzed. Results: B-cell lymphoma patients showed lower fecal microbiota richness/evenness ( Conclusions: This study identifies distinct patterns of gut microbiota dysbiosis across B-cell lymphoma subtypes and explores their correlations with host immune parameters.

Indexed as

BacteriaGastrointestinal MicrobiomeLymphoma, B-CellAdultAgedAged, 80 and overCytokinesFecesFemaleHumansMaleMiddle AgedRNA, Ribosomal, 16SCytokinesRNA, Ribosomal, 16S16s rDNA sequencingB-cell lymphomagut microbiotamicroecology-immune axispathological subtype

Identifiers

PMID41357232
PMCPMC12675396

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.