ArticleFrontiers in immunology2025
Case Report: Exploring the underlying mechanisms of psoriasis comorbid with sarcoidosis: insights from a case of coexisting immune-related disorders.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psoriasis, a chronic inflammatory disease characterized by hyperactivation of the Th1/Th17 axis, is increasingly recognized for its comorbid mechanisms with other immune-related disorders. This article reports a rare case. The case involves a 62-year-old woman with a 30-year history of chronic plaque psoriasis who developed sudden annular nodules on both lower limbs. Histopathology revealed non-caseating epithelioid granulomas, and PET-CT confirmed multi-system involvement, leading to a diagnosis of sarcoidosis. After three months of oral MTX therapy, the sarcoidosis skin lesions and psoriatic lesions showed significant improvement. The rare instance of coexistence suggests that chronic Th-cell immune activation may disrupt immune homeostasis through distinct pathways. This study presents clinical insights for an understanding of the mechanisms underlying immune-related comorbidities. It emphasizes the importance of implementing dynamic immune monitoring in the management of chronic inflammatory skin diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.