ArticleFrontiers in immunology2025
NETs promote invasive behavior of fibroblast-like synoviocytes through GPIbα in rheumatoid arthritis.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Therapeutic potential of 6-BIO in modulating oxidative stress and inflammation in rheumatoid arthritis.Molecular biology reports · 2026Article
- Atherosclerosis in Rheumatoid Arthritis: The Role of NETs and Management.Journal of inflammation research · 2026Review
- Mechanistic Study of Yibi Decoction in Treating Rheumatoid ArthritisEndocrine, metabolic & immune disorders drug targets · 2026Article
- Mapping benefit, risk, and opportunity in PAD4 inhibition.Frontiers in immunology · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Neutrophil extracellular traps (NETs) have been implicated in rheumatoid arthritis (RA) pathogenesis, yet their effects on fibroblast-like synoviocytes (FLS) remain unclear. This study aims to investigate the role of NETs in RA FLS migration, proliferation, and invasion, as well as the underlying molecular mechanisms. Methods: NETs formation was assessed in neutrophils isolated from RA patients and healthy controls (HC) using immunofluorescence staining. RA FLS were stimulated by RA or HC derived NETs, and migration was evaluated via wound healing assays. RNA sequencing (RNA-seq) identified differentially expressed genes in FLS, validated by qPCR. The expression and localization of glycoprotein Ib alpha (GPIbα) in RA synovium were examined by immunohistochemistry. GPIbα was knocked down in FLS to assess its role in proliferation and migration. A collagen-induced arthritis (CIA) model was used to study the effect of NETs inhibition on RA progression. Results: RA neutrophils produced more NETs than HC neutrophils. RA NETs enhanced FLS migration and proliferation, and RNA-seq revealed upregulation of Conclusion: Our findings reveal that NETs promote RA progression by inducing FLS proliferation and migration through GPIbα. Consequently, targeting NETs formation or GPIbα represents a promising therapeutic strategy to mitigate RA.
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Registered trials
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