Evidence map›Paper›PMID 41357055›Full record

ArticleJournal of the ASEAN Federation of Endocrine Societies2025

A Difficult Case of Ectopic ACTH Syndrome: Is Treatment Possible Even Without Accurate Localization?

Adam I Kaplan, Liam Clifford, Ammar Wakil

Abstract readCase Reports
In one paragraph

Article in Journal of the ASEAN Federation of Endocrine Societies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adam I KaplanDepartment of Endocrinology, Gosford Hospital, Gosford, New South Wales, Australia.
Liam CliffordDepartment of Endocrinology, Gosford Hospital, Gosford, New South Wales, Australia.
Ammar WakilDepartment of General Medicine, Wyong Hospital, Wyong. New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Occult ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a relatively rare form of ACTH-dependent Cushing's Syndrome (CS). We describe a middle-aged female with symptomatic CS, where despite thorough investigations including hormone suppression testing, multiple imaging modalities, and inferior petrosal sinus sampling (IPSS), an ectopic source could not be demonstrated. Our case demonstrates that ketoconazole can be an effective therapeutic to suppress cortisol production even when the source of ectopic ACTH production is unknown. However, long-term evaluation is required.

Indexed as

ACTH Syndrome, EctopicCushing SyndromeKetoconazoleAdrenocorticotropic HormoneFemaleHumansHydrocortisoneMiddle AgedTreatment OutcomeAdrenocorticotropic HormoneHydrocortisoneKetoconazoleCushing syndromeectopic ACTH syndromehypercortisolismketoconazole

Identifiers

PMID41357055
PMCPMC12680846

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.