ArticleCureus2025
Could Methotrexate Be an Option for Managing Ectopic Pregnancies in Women With an Initial High β-Human Chorionic Gonadotropin Level?
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ectopic pregnancy is a common clinical problem with a formal evidence-based practice guideline. In this case, the patient declined the recommended standard management following counselling. In this report, we present the case management, time to resolution, and patient perspective for refusal of standard treatment. We reviewed the recommendations of the National Institute for Health and Care Excellence (NICE) and American College of Obstetricians and Gynecologists (ACOG) guidelines with the supporting evidence, along with other published studies evaluating the effectiveness of methotrexate with varying initial levels of β-human chorionic gonadotropin (β-hCG). Informed patient choice, as a part of modern medical practice, is addressed with reference to novel practices in obstetrics. We questioned whether methotrexate could be an option for these women following thorough counselling. The significance of a persistent ectopic mass after clinical resolution is highlighted as an area that requires further research to evaluate the benefits and risks of this treatment option.
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