Evidence map›Paper›PMID 41356909›Full record

ArticleCureus2025

Intercostal Cryoanalgesia in Pediatric Nuss Repair for Pectus Excavatum: A Three-Case Series From Ecuador.

Juan Esteban Cruz Álvarez, Jose Antonio Daza Merizalde, Michele José María Ugazzi Betancourt, Giancarlo Daniel Sánchez Salazar

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Juan Esteban Cruz ÁlvarezPediatric Surgery, Universidad San Francisco de Quito, Quito, ECU.
Jose Antonio Daza MerizaldePediatric Surgery, Hospital Pediátrico Baca Ortíz, Quito, ECU.
Michele José María Ugazzi BetancourtPediatric Surgery, Universidad San Francisco de Quito, Quito, ECU.
Giancarlo Daniel Sánchez SalazarPediatric Surgery, Universidad San Francisco de Quito, Quito, ECU.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pectus excavatum is the most common congenital anterior chest wall deformity, and although the Nuss procedure is the standard of care, postoperative pain remains a clinical challenge. Here, we report a three-case series from Quito, Ecuador, evaluating ultrasound-guided intercostal cryoanalgesia integrated with pediatric Nuss repair. Three adolescent males (14-15 years) with moderate-to-severe deformity (mean Haller index: 3.51) underwent two-bar Nuss repair with lateral stabilizers. Bilateral intercostal cryoanalgesia (T3-T8; two minutes per nerve; CO₂ cryoprobe) was performed at three timings: intraoperative (day zero), immediate preoperative (-24 hours), and delayed preoperative (-90 days). A standardized multimodal protocol included bilateral pectoralis nerve II blocks, a type of ultrasound-guided regional anesthetic technique used to manage chest wall pain, plus a dexmedetomidine infusion and scheduled non-opioid analgesics; tramadol was reserved for rescue via the intravenous route. There were no intraoperative complications or intensive care admissions. Pain decreased rapidly, as measured by the Visual Analog Scale, with day one scores of 2-3 and day three scores of 1-2; opioid rescue was minimal (0-1 dose within 24-48 hours), and the length of stay was short (3-4 days). No neurologic deficits or wound complications were observed. These observations support the feasibility and safety of intercostal cryoanalgesia in a middle-income setting and suggest that immediate preoperative application (-24 hours) may provide earlier analgesic onset than intraoperative timing, warranting larger comparative evaluations.

Indexed as

intercostal cryoanalgesialow-resource settingsnuss procedurepectus excavatumpediatric thoracic surgerypostoperative pain management

Identifiers

PMID41356909
PMCPMC12679045

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