Evidence map›Paper›PMID 41356872›Full record

ReviewCureus2025

Critical Evaluation of Assessment and Decision-Making in Complex Limb Fracture Management: A Review of Current Practice and Emerging Trends.

Kayaththery Varathan, Havil Stephen Alexander Bakka, Adele Zacken, Daniel I Koshy, Jasmin Kirupananthan, Mustafa O Albayati, Mohammed A Bedair, Shanmukha Koppolu, Aleksander Rula, Uzair Khan

Abstract readReview
In one paragraph

Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kayaththery VarathanSurgery, Barts Health NHS Trust, London, GBR.
Havil Stephen Alexander BakkaNeurosurgery, Royal Sussex County Hospital, Brighton, GBR.
Adele ZackenGeneral Surgery, Barking, Havering and Redbridge University Hospitals NHS Trust, London, GBR.
Daniel I KoshyTrauma and Orthopaedics, Queen Mary University of London, London, GBR.
Jasmin KirupananthanGeneral Medicine, St Helier Hospital, London, GBR.
Mustafa O AlbayatiTrauma and Orthopaedics, Royal London Hospital, London, GBR.
Mohammed A BedairTrauma and Orthopaedics, Barts Health NHS Trust, London, GBR.
Shanmukha KoppoluTrauma and Orthopaedics, Barts Health NHS Trust, London, GBR.
Aleksander RulaOrthopaedic Surgery, Queen Mary University of London, London, GBR.
Uzair KhanTrauma and Orthopaedics, Ipswich Hospital, East Suffolk and North Essex NHS Foundation Trust, Ipswich, GBR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complex limb injury involves severe trauma to the bone, muscle, nerves, and vessels, typically resulting from high-energy incidents such as road traffic collisions, falls, or explosions. Prompt assessment and stabilisation are critical due to the life- and limb-threatening nature of these injuries. Management requires a multidisciplinary approach involving orthopaedic, vascular, and plastic surgeons. The decision between limb salvage and amputation depends on numerous factors, including the mechanism of injury, soft tissue damage, ischaemia time, and patient-specific considerations such as age, comorbidities, and psychological impact. Although several scoring systems (such as the Mangled Extremity Severity Score; Nerve Injury, Ischemia, Soft Tissue Injury, Skeletal Injury, Shock, and Age of Patient; and the Ganga Hospital Open Injury Severity Score) exist to guide clinical decision-making, they have limited predictive value for outcomes and are not universally applicable, particularly in upper limb injuries. Advances such as CT angiography and modern trauma networks have improved assessment, but no single tool reliably dictates management. Systematic reviews and cohort studies show similar long-term physical outcomes between amputation and salvage, though psychological results may favour salvage. Ultimately, decisions must be individualised, integrating clinical judgment, patient values, and multidisciplinary expertise to achieve the best functional and holistic outcomes.

Indexed as

complex limb injurylimb injurylimb-salvage surgerylower limb amputationlower limb traumamangled limb

Identifiers

PMID41356872
PMCPMC12681261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.