ReviewCureus2025
Association Between Pulse Wave Velocity and Cerebral Small Vessel Disease: A Scoping Review.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Clinical Relevance and Potential Applications of Brachial-Ankle Pulse Wave Velocity: Current Evidence and Future Perspectives.Journal of clinical medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral small vessel disease (CSVD) is a common condition affecting the small vessels of the brain and is often linked to dementia and strokes. Its prevalence increases with age, making noninvasive predictors essential for early intervention and management. Arterial stiffness, commonly measured via pulse wave velocity (PWV), has been proposed as a marker of CSVD, but differences in PWV measurement methods, CSVD markers, and confounders such as age and vascular risk complicate this relationship. This scoping review aimed to clarify the association between PWV and CSVD by searching four databases (EMBASE, Ovid MEDLINE, Web of Science, and CINAHL) for peer-reviewed articles written in English published between 2014 and 2024 that included both PWV and at least one major CSVD biomarker: (1) white matter hyperintensities (WMH), (2) lacunar infarcts (LI), (3) fractional anisotropy (FA), (4) cerebral microbleeds (CMB), or (5) perivascular spaces (PVS). Of 1,345 articles initially identified, 53 met the inclusion criteria. The findings suggest a general trend of higher PWV being associated with increased WMH volume, greater PVS severity, decreased FA, and the presence of LI, with several studies also linking the CSVD-PWV association to cognitive decline, stroke recurrence, and depression. The most definitive associations were found between PWV and the presence of WMH. These findings support PWV's potential as an early predictor of CSVD severity and progression, provided that suitable standardization of measurement methods and further longitudinal research are done. The association between PWV and cognitive decline, stroke risk, and functional recovery further underscores PWV in a potential role as a predictive marker in CSVD management. Identifying PWV as a modifiable risk factor emphasizes the importance of early detection, lifestyle intervention, and cardiovascular risk management in mitigating CSVD progression and outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.