ArticleFrontiers in nutrition2025
Efficacy of a multi-nutrient dietary supplement on improving decision fatigue in video gamers.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.
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Who cites it
2 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of nutritional interventions on competitive performance and dose‒response relationships among esports players of different skill levels: a systematic review and three-level meta-analysis.Journal of the International Society of Sports Nutrition · 2026Pooled it
- Exercise interventions and multidimensional cognitive function in esports players: a systematic review and meta-analysis of randomized controlled trials.Frontiers in psychology · 2026Pooled it
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Gamers can experience decision fatigue, affecting decision-making and overall performance. This pilot study evaluated a multi-nutrient supplement called Numin on decision fatigue, video game performance, cognitive function, and mouse and keyboard input mechanics assessed as physical aspects of video gamers. Formulated with active ingredients like Methylsulfonylmethane, L-Tyrosine, Rhodiolife Methods: Healthy adults with at least "Silver" skill rating were enrolled from February 6 to 13, 2022 in Arizona, USA. Participants played 10 competitive games of League of Legends (LoL). The primary endpoint was the change in decision fatigue between study groups, measured using Decision Fatigue Scale (DFS) and video game performance. Results: DFS scores were lower in the intervention group than in the placebo group, while cognitive assessment scores were higher in the intervention group for most tasks compared to the placebo group. However, these differences were not significant. Video game performance significantly improved in the intervention group regarding average deaths when losing, gold spent percentage difference, and perhaps most importantly, win rates compared to the placebo group ( Discussion: Numin is hypothesized to exert neuroprotective effects by improving glutamate re-uptake and protecting against excitotoxic injury, thereby supporting neuronal health and neurotransmission. While direct measures of decision fatigue and cognition did not show statistically significant improvements, these mechanisms may contribute to the observed enhancements in gaming performance and win rates by mitigating the molecular and cellular events underlying cognitive decline under prolonged demands. Our findings indicate that Numin improved video game performance in LoL gamers, suggesting it may support cognitive function during intense tasks. This study highlights the potential application and benefits of such a supplement in individuals undergoing cognitively intense tasks, such as gaming.
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